Oral health

A holistic well-being approcach: from the gut to the mouth

Other emerging areas of interest for probiotics applications are linked to the presence of the local microflora to interact within the specified regions. The oral cavity is one of those regions and a place where various health concerns can be addressed.

The alteration of the oral microflora can lead to the over-development of certain commensal or pathogenic bacteria involved in local infections or oral problems; bacteria represent a common component of all major oral diseases.

 

Dental caries

With a prevalence close to 100% in adults, and 60 to 90% in school-age children over the world (WHO), dental caries are defined as an infectious disease of bacterial origin, leading to the destruction of the enamel, dentin and/or cementum of the tooth. Streptococcus mutans, naturally present in healthy individuals has been identified as a key cariogenic bacterium (Laleman 2014). Other culprits include S. sobrinus, which works in synergy with S. mutans by suppressing the specific immune response of the host, or Actinomycetes which come as secondary colonizers of the tooth decay.

Gingivitis

Gingivitis is an inflammation of the gum caused by bacteria or dental plaque accumulation affecting around half of the adult population. Serious cases, if not treated, can evolve into periodontitis (deterioration of the bone), a major cause of tooth loss. Various anaerobic bacteria protected from oxygen in the gingival crevicae or within the dental plaque, are responsible for gum infection: Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Actinomyces odontolyticus, Actinomyces naeslundii…

Halitosis

Halitosis, or bad breath, affects 25% of the European, American and Japanese populations and 6% have permanent oral malodour (Filippi & Meyer 2004). This condition can have a serious impact on quality of life: in the US only, almost $1 billion a year is spent on products to manage bad breath. It is mainly due to volatil sulfur compounds produced by anaerobic Gram negative bacteria.

Candidiasis

It is caused by yeast infection with Candida albicans. Under normal conditions, C. albicans is a commensal yeast present in the mouth of 80% of the population.  A disequilibrium of the microflora in favour of C. albicans leads to overgrowth and infection.

Ear nose trhroat infections

Common ear nose throat infections can originate from disequilibrium of the oral cavity microflora, such as Streptococcal pharyngitis (due mainly to S. pyogenes), acute otitis media…

  •  L. rhamnosus HA-111
  • L. brevis HA-112
  • L. salivarius HA-118
  • L. plantarum HA-119
  • L. helveticus HA-128
  • L. fermentum HA-179
  • L. reuteri HA-188
  • S. salivarius ss. therm. HA-110
  • L. rhamnosus Rosell®-11
  • L.helveticus Rosell®-52
  • L. rhamnosus Rosell®-343
  • B. longum Rosell®-175
  • S. salivarius ss. therm. Rosell®-83
  • L. helveticus Lafti®L10

See which proprietary probiotic strains are selected for their potential applications on Tooth decay, Gingivitis, Halitosis, Candidiasis

All of our strains in Lallemand Health Solutions’ collection have been clearly identified and documented based on their principal properties and health Benefits.

Reliable Strains

Having conducted extensive research over the past 80 years, Lallemand Health Solutions has assured its strains are safe for human consumption. Today, the company’s commitment to safety is as firm as ever, and it continues to focus particular attention on such areas as genome decryption, resistance to antibiotics, and in vivo toxicological studies, among others.

 Stable Strains

Lallemand Health Solutions’ strains are carefully selected not only for their health benefits, but also for their ability to survive through their arrival at their action site. In that regard, the company has developed an ongoing research program for improving the production and formulation of its products in order to provide the organism with the number of bacteria it needs, where it needs them.

Documented Strains

Lallemand Health Solutions scientifically documents its strains internally, but also through its numerous partnerships with the scientific community.

Strains Innovations:

Some of our strains have been pushed in the R&D process, and can be offered in different versions :

  • Non Dairy strains (ND) :
  • Probiocap® Microencapsulated strains (ME) : Thanks to Probiocap® technology

 


Glossary

The Lactobacillus genus encompasses more than 25 species and includes a diverse range of organisms. These organisms are strictly fermentative, aerotolerant or anaerobic and have complex nutritional requirements. Using glucose as a carbon source, lactobacilli are either homofermentative (more than 85% of their formulation is of lactic acid) or heterofermentative (production of lactic acid, carbon dioxide, ethanol or acetic acid).
Main characteristics:

  • Maintain a healthy and balanced intestinal microbiota and reduce the incidence of intestinal infections.
  • Are often recommended for the prevention of intestinal microbiota problems and diarrhea related to antibiotic treatment.
  • Contribute to the modulation of specific and non-specific immune defenses.

Contribute to the modulation of specific and non-specific immune defenses.

The Bifidobacterium genus is gram-positive, anaerobic and often ramified. It is the predominant bacterial group in the intestinal flora of healthy newborns that are breastfed, representing more than 95% of all bacteria present. However, the number of these organisms diminishes with time (starting from weaning) to eventually represent an average of 25% of a healthy individual’s intestinal flora.

Main characteristics :

Several studies have clearly identified that bifidobacteria can be effective in the prevention and reduction of diarrheas related to antibiotic treatment or resulting from the rotavirus in children. Anaerobic bacteria belonging to the Bifidobacteria sub-family are also beneficial for the well-being of the host, both during childhood and in later stages of life.

Moreover, they contribute to the modulation of specific and non-specific immune defenses.

 

Streptococcus thermophilus is one of the two bacteria required to make yoghurt. Although its genus, Streptococcus, includes some pathogenic species, food industries consider S. thermophilus a safer bacterium than many other Streptococcus species. It is an aerobic bacteria Gram+ spherical to ovoid cocci in pairs to long chains of 0.7 to 0.9 µm. Since it is homofermentative, it produces lactic acid (only L(+) isomer) and folate during fermentation, which is an essential requirement for the growth and colonization of Lactobacilli in mouth. Moreover yogurt culture has a strong potential for H202 production that will help kill the anaerobic bacteria responsible for oral disbalance.

Main characteristics:

  • Acidifies the mouth
  • Produces H202 that helps kill pathogens
  • Creates the conditions for growth of Lactobacilli that will bind to cells and express its competitive exclusion properties againt pathogens

 Lallemand Health Solutions offers one of the largest portfolios of probiotic strains with potential application in oral health. By combining such documented strains into adapted galenic forms (e.g. xylitol-based orodispersible powders, chewable tablets…), it is possible to develop innovative solutions to answer consumers demand for natural, gentle, preventive oral care solutions to maintain a positive oral environment and microflora, which can contribute to good overall oral health.

Clinical substantiation of probiotic efficacy in oral health is still in its infancy, but several studies have suggested the benefits of certain probiotics in the prevention of oral candida, caries, halitosis, and gum diseases prevention (Cagetti et al., 2013).

Lallemand Health Solutions probiotic proprietary strains with their potential application areas in oral care (relevance rating from + to +++ for the highest).

Strains TOOTH DECAY GINGIVITIS HALITOSIS CANDIDIASIS
L. rhamnosus HA-111 ++     +
L. brevis HA-112 ++ +   +
L. salivarius HA-118 + +    
L. plantarum HA-119 +   + +
L. helveticus HA-128 +   + +
L. fermentum HA-179 +     +
L. reuteri HA-188 ++ ++ +  
S. salivarius HA-110     ++  
L. rhamnosus Rosell®-11 + +++    
L. rhamnosus Rosell®-343 +++ +++    
S. salivarius Rosell®-83     ++  
L. helveticus Lafti®L10   +++   +++

 Lallemand Health Solutions has also developed a specific combination, called Oralis SB* clinically documented in tooth decay and gingivitis

* Oralis SB marketed under Darolac® brand in India that combines : S.boulardii + Lactobacillus helveticus Rosell®-52 + Lactobacillus rhamnosus Rosell®-11 + Bifidobacterium longum Rosell®-175.
That combination as a mix of bacterias and yeast is named PR-Probiotic 2.0.mediator-probiotic2

 

 

 

 


Glossary

The Lactobacillus genus encompasses more than 25 species and includes a diverse range of organisms. These organisms are strictly fermentative, aerotolerant or anaerobic and have complex nutritional requirements. Using glucose as a carbon source, lactobacilli are either homofermentative (more than 85% of their formulation is of lactic acid) or heterofermentative (production of lactic acid, carbon dioxide, ethanol or acetic acid).
Main characteristics:

  • Maintain a healthy and balanced intestinal microbiota and reduce the incidence of intestinal infections.
  • Are often recommended for the prevention of intestinal microbiota problems and diarrhea related to antibiotic treatment.
  • Contribute to the modulation of specific and non-specific immune defenses.

The Bifidobacterium genus is gram-positive, anaerobic and often ramified. It is the predominant bacterial group in the intestinal flora of healthy newborns that are breastfed, representing more than 95% of all bacteria present. However, the number of these organisms diminishes with time (starting from weaning) to eventually represent an average of 25% of a healthy individual’s intestinal flora.

MAIN characteristics :

Several studies have clearly identified that bifidobacteria can be effective in the prevention and reduction of diarrheas related to antibiotic treatment or resulting from the rotavirus in children. Anaerobic bacteria belonging to the Bifidobacteria sub-family are also beneficial for the well-being of the host, both during childhood and in later stages of life.
Moreover, they contribute to the modulation of specific and non-specific immune defenses.

Streptococcus thermophilus is one of the first strains which was found to be a promoter of health and longevity by the Nobel Prize winner Elie Metchnikoff in 1907. S. thermophilus is found in fermented milk products, and is generally used in the production of yoghurt. Although its genus, Streptococcus, includes some pathogenic species, food industries consider S. thermophilus a safer bacterium than many other Streptococcus species. S. thermophilus can be used as an adjunct in formulation as it is a great producer of diverse nutrients essential for the growth and colonization of good bacteria in situ. S. thermophilus is also recognized for its strong potential to produce Hydrogen Peroxide (H202) which inhibits growth of pathogens and undesirable micro-organisms.

 Saccharomyces boulardii is a wild tropical yeast that was discovered in Asia in 1923 by the French scientist, Henri Boulard. Boulard succeeded in isolating it from the peel of various tropical fruits (lychees) after having observed that indigenous populations were using the peels of such fruit as antidiarrheals. Saccharomyces boulardii is the only probiotic yeast. It has been used for decades in Europe and belongs to the same family as Saccharomyces cerevisiae but differs on the genetic, metabolic and physiological levels. It is unicellular and globular, and it reproduces by budding, which leaves scars on its surface.

Main Characteristics:

  • Prevents and treats diarrheas related to antibiotic treatment
  • For maintenance and reestablishment of GIT microflora
  • For prevention of travel diarrhea
  • Treats diarrhea in children