Our Values Shine Through Our Complete Probiotic Solutions 

Experts in probiotic formulations, we offer a full line of ready-to-market probiotic formulas and help our partners to design their own custom and complex formulations using Harmonium, Lafti® or Rosell® probiotic strains. We are also one of the very few probiotics manufacturers that produce the probiotic yeast  saccharomyces boulardii, which can be offered as pure active ingredient or added to custom bacteria-based formulations.  All our strains are systematically screened for purity, efficacy, innocuity, and documented for their modes of action to identify their potential health benefits. 

Best-in-Class Documented Formulas Supported By: 

  • An integrated research and development platform from in vitro and in vivo models to clinical studies 
  • Regulatory and compliance: complete registration dossier and claims available 
  • Sales and marketing: product training and communication tools

We Support Our Partners’ Creativity with Specific Customized Blends 

Let us guide you through our strains offer and narrow down for you the best strains and combinations with complementary effects to meet your needs. 

L. rhamnosus Rosell®-11
L. rhamnosus GG
L. rhamnosus HA-111
L. rhamnosus HA-114
L. helveticus Rosell®-52
L. helveticus LAFTI® L10
L. helveticus HA-122
L. helveticus HA-128
L. acidophilus Rosell®-418
L. plantarum Rosell®-1012
L. plantarum ROSELLA
L. plantarum HA-119
L. paracasei LAFTI® L26
L. paracasei HA-196
L. paracasei Rosell®-215
L. paracasei HA-108
L. brevis HA-112
L. salivarius HA-118
L. fermentum HA-179
L. reuteri HA-188
L. reuteri Rosell®-444
L. gasseri HA-275
L. crispatus Rosell®-470

B. bifidum Rosell®-71
B. bifidum HA-132
B. longum Rosell®-175
B. longum HA-135
B. lactis LAFTI® B94
B. lactis HA-194
B. infantis Rosell®-33
B. infantis HA-116
B. breve Rosell®-70
B. breve HA-129

S. boulardii CNCM I-1079

Bacillus subtilis Rosell®-179
Bacillus subtilis HA-124
Bacillus coagulans Rosell®-449
Lactococcus lactis Rosell®-1058
Lactococcus lactis HA-136
Enterococcus faecium Rosell®-26
Enterococcus faecium HA-127
Pediococcus acidilactici HA-524
Streptococcus thermophilus Rosell®-83
Streptococcus thermophilus HA-110

Choose Your Dosage Form and Packaging Options 

We conduct in-house stability studies to monitor our strains and their specific combinations, the performance of packaging, ingredient combination and specific temperatures: refrigerated conditions, zone II, zone IVb according to ICH guidelines. From the selection of added-value ingredients up to the finished product in most suitable packaging for your customer target, leverage the science of our Expert’Biotics and take advantage of Lallemand Health Solutions’ vertical integration to achieve your market goals.

Dosage Forms

  • Acid-resistant capsules
  • Capsules
  • Chewable tablets
  • Enteric-coated capsules
  • Gummies
  • Lozenges
  • Orodispersible powder
  • Powder
  • Sprinkle capsules

Packaging Options

  • ACLAR/Alu-alu blisters
  • HDPE / CSP bottles
  • Sachets / Sticks

Probiotics With Added-Value Ingredients

Lallemand Health Solutions applied research facility can assess ingredient compatibility before industrial scale up. The list of pre-approved ingredients with proven compatibility with probiotic strains and blend, range from vitamins and minerals to botanical extracts to prebiotics and a wide selection of flavors. Several of these ingredients are backed by specific approved health claims, depending on local regulation. 


  • Vitamin B1
  • Vitamin B2
  • Vitamin B6
  • Vitamin B9
  • Vitamin C
  • Vitamin D3
  • Lalmin® VitaD


  • Calcium
  • Cooper
  • Lalmin® Cr
  • Lalmin® Se
  • Lalmin® Zn
  • Magnesium
  • Zinc


  • Biotis GOS
  • FOS
  • GOS
  • HMO
  • IMOs
  • Organic acabia fiber
  • XOS


  • Borage oil
  • Cranberry oil
  • Flax seed oil
  • Grape seed oil
  • Pumpkin seed oil
* For ComboCap®’Biotics formulations


  • Ashwagandha
  • CoQ10
  • Cranberry
  • GABA
  • M-GARD®
  • Melatonin
  • Safr’Inside™


  • Apple
  • Banana
  • Grape
  • Mint
  • Orange
  • Plum
  • Raspberry
  • Strawberry
  • Tropical
  • Vanilla

Protective Technologies for Probiotics Optimal Survival and Efficacy 

The activity and efficacy of probiotics depend on their viability through the digestive tract, their primary site of action. From the manufacturer’s plant to the consumer’s gut, they must survive many stressors. Lallemand Health Solutions has developed a range of technologies to protect probiotics to offer optimal probiotic survival and versatile applications.  

A Unique Global Probiotic Entity Vertically Integrated from Lab to Shelf 

Full control is key to offer probiotic strains and blends, or custom formulations produced to the highest quality standards. As a vertically integrated probiotics supplier, we control the overall manufacturing process from lab to shelf and can deliver from bulk powder down to the finished product. Each step is expertly supported by internal quality, regulatory and compliance, research and development, scientific affairs, technical support, and marketing teams. Delivering the best probiotic strains and products is just the start; we make sure each client gets our full attention and each project benefits from a customized service plan. Ongoing support from our committed team is embedded in our values.

Probiotics Production Expertise – How Are Probiotics Made?

The first step in producing probiotic products is to select the bacteria strain that will be produced. As these proprietary strains are the fruit of years of research and expertise, safety copies are kept at low temperatures in secured bacterial culture collections. They are also deposited in renowned international culture collections. The selected strain is then thawed, transferred into a culture media, and incubated to ensure optimal growth. Although probiotic products can combine multiple bacteria strains, each single strain must individually go through the upstream process to control and monitor their specific growing conditions. The small cryotube is upscaled into larger volumes of culture media until it reaches the required volume and bacterial concentration for further inoculation.
The preparation of culture media for industrial production starts in parallel to the inoculum process. Raw materials are received, thoroughly inspected to assess their quality, and ensure their conformity to specifications, and then quarantined before further processing. Once released by the Quality Control department, the raw materials are assembled on pallets according to the proprietary recipes developed for each strain. Each raw material is carefully weighed in the dedicated weighing area. Before use, all raw materials are double-checked against the picking list by the production operator. Finally, all weighed materials are dissolved into water using a high-shear mixer to become culture media.
The sterilized culture medium and bacteria-filled inoculum are transferred to the pre-fermenter. This action and the next ones are performed through a sophisticated closed-circuit system to prevent contaminations. From the pre-fermenter to the fermenter, the bacterial culture carries on growing and multiplying under optimal conditions for biomass production. Once bacteria growth has considerably slowed down and the fermentation broth has reached the desired volume, it is cooled down and transferred to the centrifuge. The centrifuge will spin the fermentation broth at very high speed to separate the elements by centrifugal force. This will result in a highly concentrated bacteria cream. At this stage cryoprotective agents are carefully added to the bacteria cream to prevent cell damage to ensure optimal strain survival during the freeze-drying process.

Now that a highly concentrated bacteria cream has been obtained, it is time to dry it further to get pure bacteria powder. Freeze-drying, also known as lyophilization, is the appropriate process to dry heat-sensitive substances like bacteria. Freeze-drying is a low temperature dehydration process that freezes the bacteria by first lowering the pressure and then removing all its frozen water by sublimation. Leveraging years of know-how, a specific combination of temperature and pressure is applied to remove any remaining moisture from the bacterial culture. This results in a cake-like freeze-dried substance which will then be ground to become pure active bacteria powder. Once quality controls have been performed to assess the powder’s purity and probiotic count, the upstream production process ends.

To create various probiotic formulations, the pure active bacteria powder will be blended with other relevant ingredients during the downstream process. Depending on the formula, pure bacteria, excipients, and/or other ingredients such as vitamins or minerals are carefully selected according to a proprietary formula, or as requested by a client. They are weighed and combined in a special bin. These bins will be fixed to a bin blender to be thoroughly mixed. The mix is transferred into identified laminated bags for refrigerated storage until further processing.

Probiotics powder and formulas can then be transformed into various dosage forms, including capsules, orodispersible powder, tablets – and even gummies or lozenges for certain strains.
As probiotics are live bacteria, further appropriate packaging is essential to ensure optimal shelf-life. The galenic forms can be packed in ACLAR/Alu-alu blisters, HDPE / CSP bottles, sachets or sticks.
At the end of the process, the finished products are placed on pallets for easy transportation and storage. Palletization ensures that the products are stable, secure, and protected from damage during shipment. The pallets are wrapped with stretch film or shrink wrap to prevent the products from falling off or shifting. The pallets are also labeled with barcodes to facilitate inventory management and traceability. Finished goods shipment and delivery to our partners is the final step of the production process, where the palletized products are loaded onto trucks, trains, ships, or planes and delivered. The shipment process involves checking the quality and quantity of the products, preparing the shipping documents, and arranging the transportation mode and route. The shipment process also requires compliance with the regulations and standards of the destination country or region, such as customs clearance, import duties, and safety inspections. The shipment process aims to deliver the products in a timely, efficient, and cost-effective manner.
Lallemand Health Solutions sales and marketing team will work with you to ensure a successful product launch. We offer various marketing support services, such as probiotics training, creating awareness through a media mix that may include social media and blog posts, providing promotional materials such as brochures and white papers, producing modes of action videos, managing press relations, and more.


Probiotic manufacturing process

We invite you inside the walls of Lallemand Health Solutions’ French plant located in Saint-Simon, to see how probiotic supplements are produced for the pharmaceutical and nutraceutical industries.

How we produce probiotics

Discover the manufacturing process of probiotics in 9 steps.